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M94A3101.TXT
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1994-10-25
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Document 3101
DOCN M94A3101
TI Mortality patterns in a hemophilia cohort followed for 14 years.
DT 9412
AU Karafoulidou A; Touloumi G; Louizou C; Markakis C; Economidou I;
Hatzakis A; Mandalaki T; Laikon Hospital, Athens, Greece.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):153 (abstract no. PB0039). Unique
Identifier : AIDSLINE ICA10/94369474
AB OBJECTIVE: To describe the long term mortality patterns in a hemophilia
cohort. METHODS: 158 hemophiliacs (149 hemophilia A, 4 hemophilia B and
5 Von Willebrand's disease) seroconverted to HIV between 1980 and 1985.
The presumed date of seroconversion was calculated by smooth models
based on spline functions (Kroner and Rosenberg, 1993, submitted). The
mean (SD) age at time of seroconversion was 26.2 (15.4), range 1.3-86.0
years. The mean (SD) duration of follow up time from seroconversion was
9.1 (2.4), median 9.8, range 1.1-12.7 years. RESULTS: By November 1993
40 patients had developed AIDS and 55 died. 31 patients died from causes
directly attributed to HIV and AIDS and 24 died from other causes. The
Kaplan Meier estimation of progression risks are shown. TABULAR DATA,
SEE ABSTRACT VOLUME. The risk of death was highly depended on age at
seroconversion (p = 0.000). Survival after diagnosis of AIDS was not
associated with age at time of AIDS. The distribution of various causes
of death among AIDS cases did not change during the follow up period
despite the substantial improvement of survival after AIDS diagnosis
which was observed after antiretroviral and PCP prophylaxis treatment (p
= 0.004). DISCUSSION AND CONCLUSIONS: The progression rate to AIDS
remains relatively slow in this hemophilia cohort. However, there is a
substantial burden of fatal diseases not formally related to AIDS.
DE Acquired Immunodeficiency Syndrome/*MORTALITY/TRANSMISSION Adolescence
Adult Age Factors Aged Aged, 80 and over Child Child, Preschool
Cohort Studies Comparative Study Follow-Up Studies
Hemophilia/*MORTALITY Human HIV Seropositivity/MORTALITY Infant
Middle Age Risk Factors Survival Analysis Time Factors MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).